Part Two of Advair Information, Focusing on Side Effects, Discontinuation or Withdrawal Effects, and Additional Information

This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.

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What are the possible side effects of fluticasone and salmeterol inhalation?

  • Serious side effects from fluticasone and salmeterol inhalation are not likely to occur.
  • If you experience any of the following serious side effects, stop using fluticasone and salmeterol inhalation and seek emergency medical attention or notify your doctor immediately:
    • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
    • chest pain or irregular heartbeats;
    • numbness, tingling, or pain;
    • a rash or unexplained open sores or bruising; or
    • worsening breathing or asthma symptoms.
  • Other, less serious side effects may be more likely to occur. Continue to take fluticasone and salmeterol inhalation and talk to your doctor if you experience
    • dry mouth, nose, or throat after use;
    • yeast (or another) infection in the mouth or throat (white patches);
    • hoarseness or deepening of the voice, cough, or sore throat;
    • nausea, vomiting, or diarrhea;
    • dizziness, headache, tremor, or nervousness.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect fluticasone and salmeterol inhalation?

  • Before using fluticasone and salmeterol inhalation, tell your doctor and pharmacist if you are taking any of the following medications:
    • another oral, nasal, or inhaled steroid;
    • a beta-blocker such as atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal), and others;
    • a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);
    • a tricyclic antidepressant such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), and others;
    • a diuretic (water pill) such as hydrochlorothiazide (HydroDiuril, Esidrix, Oretic, Microzide), chlorothiazide (Diuril), furosemide (Lasix), and others;
    • caffeine (in food or medicines), a diet medicine, or a decongestant such as pseudoephedrine or phenylephrine;
    • a protease inhibitor such as ritonavir (Norvir); or
    • an antifungal medicine such as ketoconazole (Nizoral) or itraconazole (Sporanox).
  • You may not be able to use fluticasone and salmeterol, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
  • Drugs other than those listed here may also interact with fluticasone and salmeterol inhalation or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

  • Your pharmacist has additional information about fluticasone and salmeterol inhalation written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Limitations and the Source of Our Online Medication Information Database

Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

Full public license and copyright information is available separately from Cerner Multum, Inc.

Version: 3.01. Revision date: 12/11/03.

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