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What are the possible side effects of lamotrigine?

• In rare cases, lamotrigine has been associated with severe and/or life-threatening rashes and hypersensitivity reactions. Seek emergency medical attention or contact your doctor immediately if you develop any skin rash; fever; hives; swelling of the lips, tongue, or face; sores in the mouth or around the eyes; or swollen lymph glands.
• Seek emergency medical attention or contact your doctor immediately if you experience increasing frequency or worsening of seizures during treatment with lamotrigine.
• Other, less serious side effects may be more likely to occur. Continue to take lamotrigine and talk to your doctor if you experience
• dizziness or drowsiness;
• blurred or double vision;
• nausea and vomiting;
• headache; or
• lack of coordination.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect lamotrigine?

• Lamotrigine interacts with many other drugs used to treat seizures. Before taking lamotrigine, tell your doctor about all other medications you are taking. You may require a dosage adjustment or special monitoring during treatment if you are taking lamotrigine alone or with other medications to treat seizures. Continue to take all medications prescribed to treat seizures exactly as directed.
• Birth control pills may decrease the amount of lamotrigine in the body. A dosage adjustment may be necessary if birth control pills are started or stopped during treatment with lamotrigine.
• Lamotrigine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if lamotrigine is taken with any of these medications.
• Drugs other than those listed here may also interact with lamotrigine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has additional information about lamotrigine written for health professionals that you may read.
• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Version: 7.01. Revision date: 10/13/03.