Part Two of Voriconazole Information, Focusing on Side Effects, Discontinuation or Withdrawal Effects, and Additional Information

This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.

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What are the possible side effects of voriconazole?

  • If you experience any of the following serious side effects, stop taking voriconazole and seek emergency medical attention or contact your doctor immediately:
    • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
    • liver problems (pale stools, yellowish skin or eyes, abdominal pain, unusual fatigue, or dark urine); or
    • a skin rash.
  • Other, less serious side effects may be more likely to occur. Continue taking voriconazole and talk to your doctor if you experience:
    • blurred vision, increased eye sensitivity to light, or other visual changes;
    • nausea, vomiting, or diarrhea;
    • headache; or
    • swelling or water retention.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect voriconazole?

  • Do not take voriconazole if you are taking any of the following drugs:
    • terfenadine (Seldane) or astemizole (Hismanal);
    • cisapride (Propulsid);
    • pimozide (Orap);
    • quinidine (Cardioquin, Quinora, Quinidex, Quinaglute, Quin-Release, Quin-G);
    • sirolimus (Rapamune);
    • rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane);
    • carbamazepine (Tegretol, others);
    • phenobarbital; or
    • an ergot medication such as ergotamine (Ergomar, Cafergot, Ercaf, Wigraine, others) or dihydroergotamine (D.H.E., Migranal).
  • The drugs listed above may interact dangerously with voriconazole, possibly resulting in dangerous side effects or decreased effectiveness of the medication.
  • Before taking voriconazole, tell your doctor if you are taking any other medicines, especially any of the following:
    • phenytoin (Dilantin, others);
    • tacrolimus (Prograf);
    • cyclosporine (Sandimmune, Neoral);
    • warfarin (Coumadin);
    • omeprazole (Prilosec), lansoprazole (Prevacid), or pantoprazole (Protonix);
    • alprazolam (Xanax), midazolam (Versed), or triazolam (Halcion);
    • atorvastatin (Lipitor), lovastatin (Mevacor), or simvastatin (Zocor);
    • vinblastine sulfate (Velban), vincristine sulfate (Oncovin), or vinorelbine (Navelbine);
    • a calcium channel blocker such as verapamil (Isoptin, Verelan, Calan, Covera-HS), amlodipine (Norvasc), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), or nisoldipine (Sular);
    • an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others;
    • an HIV protease inhibitor such as saquinavir (Fortovase, Invirase), lopinavir-ritonavir (Kaletra), ritonavir (Norvir), or nelfinavir (Viracept); or
    • an HIV non-nucleoside reverse transcriptase inhibitor such as efavirenz (Sustiva), delavirdine (Rescriptor) or nevirapine (Viramune).
  • You may not be able to take voriconazole, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
  • Drugs other than those listed here may also interact with voriconazole. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

  • Your pharmacist has additional information about voriconazole written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

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Version: 2.02. Revision Date: 2/14/03.

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