Part Two of Hydrodiuril Information, Focusing on Side Effects, Discontinuation or Withdrawal Effects, and Additional Information

This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.

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What are the possible side effects of hydrochlorothiazide?

  • If you experience any of the following serious side effects, stop taking hydrochlorothiazide and seek emergency medical attention or contact your doctor immediately:
    • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
    • unusual fatigue;
    • abnormal bleeding or bruising;
    • yellow skin or eyes;
    • confusion;
    • irregular heartbeats or a fluttering feeling in the chest; or
    • little or no urine.
  • Other, less serious side effects are more likely to occur. Continue to take hydrochlorothiazide and talk to your doctor if you experience
    • dizziness, especially when rising from sitting or lying down;
    • tingling or numbness in the arms, legs, hands, or feet;
    • excessive urination;
    • muscle weakness or cramps;
    • increased hunger or thirst;
    • nausea or decreased appetite;
    • abdominal pain;
    • sensitivity to sunlight; or
    • impotence.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect hydrochlorothiazide?

  • Before taking hydrochlorothiazide tell your doctor if you are taking any of the following medications:
    • lithium (Lithobid, Eskalith, others);
    • digoxin (Lanoxin, Lanoxicaps);
    • the cholesterol-lowering drugs cholestyramine (Questran) or colestipol (Colestid);
    • a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin), naproxen (Naprosyn, Anaprox, Aleve), ketoprofen (Orudis, Orudis KT, Oruvail), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), etodolac (Lodine), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), fenoprofen (Nalfon), ketorolac (Toradol), or flurbiprofen (Ansaid);
    • a diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide (Orinase), and others; or
    • a steroid medicine such as cortisone (Cortone), dexamethasone (Decadron, Hexadrol), hydrocortisone (Cortef, Hydrocortone), prednisone (Orasone, Deltasone), prednisolone (Delta Cortef, Prelone), methylprednisolone (Medrol), and others.
  • You may not be able to take hydrochlorothiazide, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medications listed above.
  • Also, before taking hydrochlorothiazide, tell your doctor if you are taking any other medicine to treat high blood pressure, water retention, heart problems, prostate problems, or another condition. Some medicines used to treat these conditions may interact with hydrochlorothiazide and the effects on your heart may be increased.
  • Hydrochlorothiazide may increase the effects of other drugs that cause drowsiness, including sedatives (used to treat insomnia), pain relievers, seizure medicines, antidepressants, alcohol, antihistamines, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.
  • Drugs other than those listed here may also interact with hydrochlorothiazide or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

  • Your pharmacist has additional information about hydrochlorothiazide written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Limitations and the Source of Our Online Medication Information Database

Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

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Version: 5.03. Revision date: 8/4/03.

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