Part Two of Hyzaar Information, Focusing on Side Effects, Discontinuation or Withdrawal Effects, and Additional Information

This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.

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What are the possible side effects of losartan and hydrochlorothiazide?

  • If you experience any of the following serious side effects, stop taking losartan and hydrochlorothiazide and call your doctor immediately or seek emergency medical treatment.
    • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
    • little or no urine;
    • unusual fatigue, abnormal bleeding or bruising;
    • yellow skin or eyes, confusion; or
    • fainting.
  • Other, less serious side effects may be more likely to occur. Continue to take losartan and hydrochlorothiazide and talk to your doctor if you experience
    • diarrhea or upset stomach;
    • muscle pain or cramps;
    • dizziness;
    • insomnia;
    • congestion or cough;
    • tingling or numbness in your arms, legs, hands, or feet;
    • excessive urination;
    • muscle weakness or cramps;
    • increased hunger or thirst;
    • nausea or decreased appetite; or
    • sensitivity to sunlight.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect losartan and hydrochlorothiazide?

  • Before taking losartan and hydrochlorothiazide, tell your doctor if you are taking
    • a potassium supplement such as K-Dur, Klor-Con, and others;
    • a potassium-sparing diuretic (water pill) such as amiloride (Midamor), spironolactone (Aldactone), or triamterene (Dyrenium, Dyazide, Maxzide);
    • a barbiturate such as phenobarbital (Luminal, Solfoton), pentobarbital (Nembutal), secobarbital (Seconal), mephobarbital (Mebaral), and others;
    • a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), naproxen (Naprosyn, Anaprox, Aleve), and others;
    • an oral diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), or tolbutamide (Orinase);
    • cholestyramine (Questran) or colestipol (Colestid);
    • lithium (Lithobid, Eskalith, others); or
    • digoxin (Lanoxin).
  • You may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
  • Drugs other than those listed here may also interact with losartan and hydrochlorothiazide or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has additional information about losartan and hydrochlorothiazide written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others and use this medication only for the indication prescribed.

Limitations and the Source of Our Online Medication Information Database

Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

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Version: 5.02. Revision Date: 2/14/03.

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