Welcome to our moduretic information (part 2) -- just click to return to front page.

Or click here for clinical trials research information on moduretic.

What are the possible side effects of hydrochlorothiazide and amiloride?

• If you experience any of the following serious side effects, stop taking hydrochlorothiazide and amiloride and seek emergency medical attention:
• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
• irregular heartbeat, shortness of breath, fatigue, confusion, weakness, numbness, or tingling, caused by high levels of potassium in your blood;
• severe mood changes;
• muscle cramping;
• black, bloody, or tarry stools;
• easy bruising or bleeding;
• blood in your urine;
• little or no urine;
• yellowing of your skin or eyes; or
• confusion.
• Other, less serious side effects may be more likely to occur. Continue to take hydrochlorothiazide and amiloride and talk to your doctor if you experience
• dizziness;
• tingling or numbness in your hands or feet;
• headache or tiredness;
• excessive urination;
• muscle weakness or cramps;
• increased hunger or thirst;
• a dry mouth;
• nausea, vomiting, diarrhea, or constipation;
• changes in weight;
• increased swelling;
• skin sensitivity to sunlight; or
• decreased sex drive.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect hydrochlorothiazide and amiloride?

• Before taking this medication, tell your doctor if you are taking any of the following medicines:
• Angiotensin-converting-enzyme inhibitors (ACE inhibitors) such as benazepril (Lotensin) or captopril (Capoten) may increase potassium in your blood, which could be dangerous when you are taking hydrochlorothiazide and amiloride.
• Other commonly used ACE inhibitors include enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and ramipril (Altace).
• Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil, Rufen, others), ketoprofen (Orudis, Orudis KT, Oruvail), and naproxen (Naprosyn, Aleve, Anaprox) may decrease the effects of hydrochlorothiazide and amiloride and may increase the risk of damage to your kidneys.
• Other commonly used NSAIDs include diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), and tolmetin (Tolectin).
• Diabetes medications such as chlorpropamide (Diabinese), tolbutamide (Orinase), tolazamide (Tolinase), glipizide (Glucotrol), and glyburide (Diabeta, Glynase, Micronase) may not be as effective in lowering your blood sugar levels when you are taking hydrochlorothiazide and amiloride. Your diabetes therapy may have to be adjusted.
• Lithium (Lithobid, Lithane, Eskalith, others) may have increased effects when taken with hydrochlorothiazide and amiloride and may cause side effects.
• Steroid medications such as hydrocortisone (Cortef, Hydrocortone, Solu-Cortef), prednisone (Orasone, Deltasone, Meticorten), methylprednisolone (Medrol, Depo-Medrol, A-MetaPred, Solu-Medrol, others), prednisolone (Prelone, Delta Cortef, Pediapred, others), dexamethasone (Decadron, Hexadrol), betamethasone (Celestone), corticotropin (Acthar, ACTH), and others may affect potassium levels in your blood.
• Warfarin (Coumadin) may have decreased effects when it is taken with hydrochlorothiazide and amiloride.
• Allopurinol (Zyloprim), probenecid (Benemid), and sulfinpyrazone (Anturane) may have reduced effects because hydrochlorothiazide and amiloride increases levels of uric acid in your body.
• Cholestyramine (Questran) and colestipol (Colestid) may decrease the effects of hydrochlorothiazide and triamterene. Hydrochlorothiazide and amiloride should be taken at least 1 hour before or 4 hours after any dose of cholestyramine or colestipol.
• Laxatives may affect potassium levels in your body. This could interfere with hydrochlorothiazide and amiloride therapy.
• Drugs other than those listed here may also interact with hydrochlorothiazide and amiloride. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about hydrochlorothiazide and amiloride written for health professionals that you may read.
• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Limitations and the Source of Our Online Medication Information Database

Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

Full public license and copyright information is available separately from Cerner Multum, Inc.

Version: 2.03. Revision Date: 2/14/03.