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What are the possible side effects of hydrochlorothiazide and lisinopril?

• If you experience any of the following serious side effects, stop taking hydrochlorothiazide and lisinopril and seek emergency medical attention:
• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
• fainting spells;
• unusual fatigue or abnormal bleeding or bruising;
• yellow skin or eyes;
• confusion;
• fever, chills, or a sore throat;
• little or no urine;
• irregular heartbeats; or
• increased swelling.
• Other, less serious side effects may be more likely to occur. Continue to take hydrochlorothiazide and lisinopril and talk to your doctor if you experience
• dizziness or lightheadedness;
• headache;
• fatigue;
• tingling or numbness in your arms, legs, hands, or feet;
• excessive urination;
• muscle weakness or cramps;
• increased hunger or thirst;
• nausea, vomiting, diarrhea, constipation, decreased appetite, or changes in taste;
• sensitivity to sunlight;
• dry, tickling cough;
• anxiety or depression; or
• itching, rash, or increased sweating.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect hydrochlorothiazide and lisinopril?

• Before taking hydrochlorothiazide and lisinopril, tell your doctor if you are taking any of the medicines listed below:
• a potassium supplement such as K-Dur, Klor-Con, and others;
• a salt substitute that contains potassium;
• another diuretic (water pill) especially triamterene (Dyrenium, Maxzide, Dyazide), spironolactone (Aldactone), or amiloride (Midamor);
• cholestyramine (Questran) or colestipol (Colestid);
• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
• an oral diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide (Orinase), and others;
• tetracycline (Sumycin, others);
• lithium (Lithane, Lithobid, Eskalith, others);
• a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor XR, Tiazac), nifedipine (Adalat, Procardia), verapamil (Calan, Verelan, Isoptin), and others;
• doxazosin (Cardura), prazosin (Minipress), or terazosin (Hytrin);
• reserpine, guanadrel (Hylorel), or guanethidine (Ismelin);
• a nitrate such as nitroglycerin (Nitrostat, Transderm-Nitro, Nitro-Dur, Nitro-Bid, Minitran, others), isosorbide mononitrate (Imdur, ISMO), or isosorbide dinitrate (Isordil, Sorbitrate);
• a pain reliever such as codeine, morphine (MS Contin, MSIR, Roxanol, others), propoxyphene (Darvocet, Darvon, Wygesic), oxycodone (Percocet, Percodan), meperidine (Demerol), and others;
• a barbiturate such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal), secobarbital (Seconal), and butabarbital (Butisol); or
• a steroid medicine such as cortisone (Cortone), dexamethasone (Decadron, Hexadrol), betamethasone (Celestone), hydrocortisone (Cortef, Hydrocortone), prednisone (Orasone, Deltasone), prednisolone (Delta Cortef, Prelone), methylprednisolone (Medrol), and others.
• You may not be able to take hydrochlorothiazide and lisinopril, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.
• Drugs other than those listed here may also interact with hydrochlorothiazide and lisinopril or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about hydrochlorothiazide and lisinopril written for health professionals that you may read.
• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

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Version: 3.05. Revision Date: 2/14/03.