Part Two of Trental Information, Focusing on Side Effects, Discontinuation or Withdrawal Effects, and Additional Information

This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.

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What are the possible side effects of pentoxifylline?

  • If you experience any of the following serious side effects, stop taking pentoxifylline and seek medical attention:
    • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
    • chest pain or an irregular heartbeat;
    • severe dizziness, headache, nosebleeds, or blurred vision;
    • nausea or vomiting; or
    • swollen feet or ankles.
  • Other, less serious side effects may be more likely to occur. Continue to take pentoxifylline and talk to your doctor if you experience
    • insomnia,
    • red eyes, or
    • nervousness.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect pentoxifylline?

  • Before taking pentoxifylline, tell your doctor if you are taking warfarin (Coumadin). Pentoxifylline may increase the effects of anticoagulants such as warfarin, which may result in bleeding.
  • Theophylline (Theo-Dur, Theo-Bid, Theolair, Theochron, Elixophyllin, Slo-Phyllin, others), aminophylline (Phyllocontin, Truphylline), dyphylline (Lufyllin, Dylix, Dilor, Neothylline), and oxtriphylline (Choledyl) may cause dangerous side effects if taken while you are taking pentoxifylline. Your dosage of these drugs may have to be reduced or blood levels closely monitored. Talk to your doctor if you are currently taking any of these medicines.
  • Tobacco may worsen your condition or decrease the beneficial effects of pentoxifylline by narrowing your blood vessels. Talk to your doctor or pharmacist if you use tobacco.
  • Drugs other than those listed here may also interact with pentoxifylline. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has additional information about pentoxifylline written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Limitations and the Source of Our Online Medication Information Database

Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

Full public license and copyright information is available separately from Cerner Multum, Inc.

Version: 5.05. Revision Date: 2/14/03.

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