Part Two of Indocin Information, Focusing on Side Effects, Discontinuation or Withdrawal Effects, and Additional Information

This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.

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What are the possible side effects of indomethacin?

  • If you experience any of the following serious side effects, stop taking indomethacin and seek medical treatment or contact your doctor immediately:
    • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
    • muscle cramps, numbness, or tingling;
    • ulcers (open sores) in the mouth;
    • rapid weight gain (fluid retention);
    • seizures;
    • black, bloody, or tarry stools;
    • blood in urine or vomit;
    • decreased hearing or ringing in the ears;
    • jaundice (yellowing of the skin or eyes); or
    • abdominal cramping, indigestion, or heartburn.
  • Other, less serious side effects may be more likely to occur. Continue to take indomethacin and talk to your doctor if you experience
    • dizziness or headache;
    • nausea, gaseousness, diarrhea, or constipation;
    • depression;
    • fatigue or weakness;
    • dry mouth; or
    • irregular menstrual periods.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect indomethacin?

  • Other prescription and over-the-counter drugs may interact with indomethacin. Tell your doctor if you are taking any of the following drugs:
    • another nonsteroidal anti-inflammatory drug (NSAID) such as ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Aleve, Anaprox), diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Motrin, Advil, others), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
    • aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), choline salicylate, and magnesium salicylate;
    • a diuretic (water pill) such as hydrochlorothiazide (HCTZ, HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Thalitone), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), spironolactone (Aldactone), and amiloride (Midamor);
    • an anticoagulant such as warfarin (Coumadin);
    • a steroid such as prednisone (Deltasone);
    • an oral diabetes medication such as glipizide (Glucotrol) or glyburide (Micronase, Diabeta); or
    • lithium (Eskalith, Lithobid, others).
  • Talk to your doctor before taking indomethacin if you are taking any other medicines, especially any of the ones listed above.
  • Drugs other than those listed here may also interact with indomethacin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

  • Your pharmacist has additional information about indomethacin written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Limitations and the Source of Our Online Medication Information Database

Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

Full public license and copyright information is available separately from Cerner Multum, Inc.

Version: 6.01. Revision date: 8/19/03.

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