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What are the possible side effects of diclofenac?

• If you experience any of the following serious side effects, stop taking diclofenac and seek medical treatment or call your doctor immediately:
• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
• muscle cramps, numbness, or tingling;
• ulcers (open sores) in the mouth;
• rapid weight gain (fluid retention);
• seizures;
• black, bloody, or tarry stools;
• blood in your urine or vomit;
• decreased hearing or ringing in the ears;
• yellowing of the skin and eyes (jaundice); or
• abdominal cramping, indigestion, or heartburn.
• Other, less serious side effects may be more likely to occur. Continue to take diclofenac and talk to your doctor if you experience
• dizziness or headache;
• nausea, gaseousness, diarrhea, or constipation;
• depression;
• fatigue or weakness;
• dry mouth; or
• irregular menstrual periods.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect diclofenac?

• Other prescription and over-the-counter drugs may increase the effects of diclofenac and cause dangerous side effects. Tell your doctor if you are taking any of the following drugs:
• other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Rufen, others), ketoprofen (Orudis, Orudis KT, Oruvail), or naproxen (Naprosyn, Aleve, Anaprox);
• other commonly used NSAIDs, including etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
• aspirin and other salicylates (forms of aspirin) such as salsalate (Disalcid), choline salicylate, and magnesium salicylate (watch the aspirin content of other over-the-counter products such as cough, cold, and allergy medicines);
• diuretics (water pills) such as hydrochlorothiazide (HCTZ, Hydrodiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Thalitone), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), spironolactone (Aldactone), and amiloride (Midamor);
• anticoagulants such as warfarin (Coumadin);
• steroids such as prednisone (Deltasone);
• alcohol;
• oral antidiabetic drugs such as glipizide (Glucotrol) and glyburide (Micronase, Diabeta);
• lithium (Eskalith, Lithobid, others);
• cyclosporine (Sandimmune, Neoral); or
• bismuth subsalicylate in drugs such as Pepto-Bismol.
• Diclofenac can also decrease the effects of other drugs, such as
• angiotensin-converting-enzyme (ACE) inhibitors, used to treat high blood pressure and other conditions, such as benazepril (Lotensin) and captopril (Capoten);
• other commonly used ACE inhibitors, including enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and ramipril (Altace); and
• beta-blockers, used to treat high blood pressure and other conditions, such as acebutolol (Sectral), metoprolol (Lopressor), propranolol (Inderal), atenolol (Tenormin), and carteolol (Cartrol).
• Drugs other than those listed here may also interact with diclofenac. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about diclofenac written for health professionals that you may read.
• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Limitations and the Source of Our Online Medication Information Database

Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

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Version: 5.03. Revision Date: 2/14/03.