This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.
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What are the possible side effects of allopurinol?
- If you experience any of the following serious side effects, stop taking allopurinol and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- blood in your urine or pain when you urinate;
- a rash;
- eye irritation;
- fever, chills, or joint aches; or
- severe nausea or vomiting.
- Other, less serious side effects may be more likely to occur. Continue to take allopurinol and talk to your doctor if you experience
- upset stomach or diarrhea;
- headache, dizziness, or drowsiness; or
- an acute attack of gouty arthritis.
- Side effects other than those listed here may also occur. Talk to your doctor about any reaction that seems unusual or that is especially bothersome.
What other drugs will affect allopurinol?
- Taking ampicillin (Principen, Omnipen, others) or amoxicillin (Amoxil, Augmentin, Trimox, Wymox, others) may increase the risk that a rash will develop during allopurinol therapy. Tell your doctor that you are taking allopurinol if you need to take ampicillin or amoxicillin.
- Thiazide diuretics (water pills) may increase the amount of allopurinol in your blood. Tell your doctor if you are taking a diuretic such as
- hydrochlorothiazide (Hydrodiuril, Hygroton, HCTZ, others),
- chlorothiazide (Diuril, others),
- chlorthalidone (Thalitone, others), or
- indapamide (Lozol).
- Allopurinol may also increase the effects of the certain other drugs. Before taking allopurinol, tell your doctor if you are taking any of the following medicines:
- azathioprine (Imuran),
- mercaptopurine (Purinethol),
- drugs used to treat cancer,
- cyclosporine (Sandimmune, Neoral),
- chlorpropamide (Diabinese),
- warfarin (Coumadin), or
- theophylline (Theochron, Theolair, Theo-Dur, others).
- You may require a dosage adjustment or special monitoring if you are taking any of the drugs listed above.
- Drugs other than those listed here may also interact with allopurinol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
Where can I get more information?
- Your pharmacist has more information about allopurinol written for health professionals that you may read.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
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Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.
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Version: 3.05. Revision Date: 2/14/03.