Part Two of Tapazole Information, Focusing on Side Effects, Discontinuation or Withdrawal Effects, and Additional Information

This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.

What are the possible side effects of methimazole?

  • In rare cases, methimazole has caused liver problems, sometimes resulting in death. Notify your doctor immediately if you develop abdominal pain, nausea, loss of appetite, yellowing of the skin or eyes, light-colored stools, or dark-colored urine. These symptoms may be early signs of liver damage.
  • Methimazole can affect the blood causing decreased levels of red and white blood cells and platelets. This may cause an increased risk of infection, serious bleeding, anemia, and other problems. Contact your healthcare provider immediately if you experience signs of infection such as fever, sore throat, coughing, or painful or difficult urination (may indicate low white blood cells); such as unusual bleeding or bruising, pinpoint red spots on the skin, nosebleeds, black, bloody, or tarry stools, or blood in urine (may indicate low platelets); or unusual tiredness or weakness (may indicate low red blood cells).
  • Other less serious side effects may be more likely to occur. Continue to take methimazole, and contact your doctor if you experience any of the following side effects:
    • headache;
    • nausea or vomiting;
    • itching; or
    • muscle aches or pains.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect methimazole?

  • Before taking methimazole, tell your doctor if you are taking any of the following medicines:
    • warfarin (Coumadin);
    • theophylline (Theo-Dur, Theochron, Elixophyllin, others);
    • digoxin (Lanoxin);
    • clozapine (Clozaril); or
    • acebutolol (Sectral), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol XL), penbutolol (Levatol), pindolol (Visken), propranolol (Inderal, InnoPran XL), or timolol (Blocadren).
  • You may not be able to take methimazole, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
  • Drugs other than those listed here may also interact with methimazole. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals and herbal products.

Where can I get more information?

  • Your pharmacist has more information about methimazole written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

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Version: 1.01. Revision date: 6/12/03.