Part Two of Progesterone Information, Focusing on Side Effects, Discontinuation or Withdrawal Effects, and Additional Information

This second section of our medication database entry focuses on potential side effects, withdrawal or discontinuation effects, and additional information, while part one covers basic drug characteristics, uses and benefits.

What are the possible side effects of progesterone topical?

  • Stop using progesterone topical and seek emergency medical attention or call your doctor immediately if you experience any of the following serious side effects:
    • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
    • shortness of breath or pain in your chest;
    • a sudden severe headache;
    • visual changes;
    • a painful, red, swollen leg;
    • numbness or tingling in an arm or leg;
    • prolonged, heavy, vaginal bleeding;
    • stomach or side pain; or
    • yellowing of your skin or eyes.
  • Other, less serious side effects may be more likely to occur. Continue to use progesterone topical and talk to your doctor if you experience
    • dizziness;
    • drowsiness;
    • headache;
    • breast pain or tenderness;
    • abdominal pain or distention;
    • joint pain;
    • perineal pain;
    • nausea, diarrhea, or constipation;
    • vaginal discharge; or
    • mood changes, anxiety, irritability, or depression.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect progesterone topical?

  • Do not use progesterone topical at the same time as other vaginal products. If you are using another vaginal product, use it at least six hours before or after a dose of progesterone topical unless specifically directed to do otherwise by your doctor.
  • Progesterone topical has not been reported to interact significantly with any other medicines. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines during treatment with progesterone topical.

Where can I get more information?

  • Your pharmacist has additional information about progesterone topical written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Although we have made considerable efforts to ensure that the information provided here is accurate, up-to-date, and complete, MedLibrary.org makes no guarantee to that effect. Drug information contained herein may be time sensitive. This medication information does not endorse drugs, diagnose patients or recommend any specific pharmacotherapy. This is an educational resource only -- intended to supplement but not to replace the expertise, skill, knowledge and judgment of medically qualified healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, please check with your doctor, nurse or local pharmacist. MedLibrary.org does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here.

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Version: 1.02. Revision Date: 2/14/03.