2,4 Dienoyl CoA reductase

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Crystallographic structure of a tetramer of the ternary complex of DECR1, hexanoyl-coenzyme A, and NADP.1
2,4-dienoyl CoA reductase 1, mitochondrial
Identifiers
Symbol DECR1
Alt. Symbols DECR
Entrez 1666
HUGO 2753
OMIM 222745
PDB 1w6u
RefSeq NM_001359
UniProt Q16698
Other data
EC number 1.3.1.34
Locus Chr. 8 q21.3

2,4 Dienoyl-CoA reductase also known as DECR1 is a protein which in humans is encoded by the DECR1 gene which resides on chromosome 8.234

This gene encodes an accessory enzyme which participates in the beta oxidation and metabolism of unsaturated fatty enoyl-CoA esters.

Contents

Pathology

Mutations in the DECR1 gene may result in 2,4 Dienoyl-CoA reductase deficiency.5

See also

References

  1. ^ PDB 1w6u; Alphey MS, Yu W, Byres E, Li D, Hunter WN (January 2005). "Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site". J. Biol. Chem. 280 (4): 3068–77. doi:10.1074/jbc.M411069200. PMID 15531764. 
  2. ^ "Entrez Gene: 2,4-dienoyl CoA reductase 1, mitochondrial".
  3. ^ Koivuranta KT, Hakkola EH, Hiltunen JK (December 1994). "Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase". Biochem. J. 304 ( Pt 3): 787–92. PMID 7818482. 
  4. ^ Helander HM, Koivuranta KT, Horelli-Kuitunen N, Palvimo JJ, Palotie A, Hiltunen JK (November 1997). "Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR)". Genomics 46 (1): 112–9. doi:10.1006/geno.1997.5004. PMID 9403065. 
  5. ^ Roe CR, Millington DS, Norwood DL, Kodo N, Sprecher H, Mohammed BS, Nada M, Schulz H, McVie R (May 1990). "2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation". J. Clin. Invest. 85 (5): 1703–7. doi:10.1172/JCI114624. PMID 2332510. 

External links

 This oxidoreductase article is a stub. You can help Wikipedia by expanding it.
v • d • e
Oxidoreductases: CH-CH oxidoreductases (EC 1.3)
1.3.1. NAD/NADP acceptor
1.3.3. Oxygen acceptor
1.3.5. Quinone
1.3.99. Other acceptors
v • d • e
Metabolism: lipid metabolism - triglyceride and fatty acid enzymes
Lipid production
Lipid degradation
see also disorders

Wikipedia content modification information:

  • This page was last modified on 13 November 2008, at 20:06.

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