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In enzymology, a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) is an enzyme that catalyzes the chemical reaction
- CTP + 2-C-methyl-D-erythritol 4-phosphate
diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Thus, the two substrates of this enzyme are CTP and 2-C-methyl-D-erythritol 4-phosphate, whereas its two products are diphosphate and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. This enzyme is also called MEP cytidylyltransferase. This enzyme participates in biosynthesis of steroids.
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Structural studies
The crystal structure of the E. coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1I52, 1INI & 1INJ, reported by Richard et al (2001), was the first one for an enzyme involved in the MEP pathway.
As of late 2007, 9 other structures have been solved for this class of enzymes, with PDB accession codes 1H3M, 1VGT, 1VGU, 1VGZ, 1VPA, 1W55, 1W57, 1W77, and 2PX7.
References
- IUBMB entry for 2.7.7.60
- BRENDA references for 2.7.7.60 (Recommended.)
- PubMed references for 2.7.7.60
- PubMed Central references for 2.7.7.60
- Google Scholar references for 2.7.7.60
- Richard SB, Bowman ME, Kwiatkowski W, Kang I, Chow C, Lillo AM, Cane DE, Noel JP (2001). "Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.". Nature Structural biology 8(7): 641–8. doi:. PMID 11427897.
- Kuzuyama T, Takagi M, Kaneda K, Dairi T and Seto H (2000). "Formation of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway". Tetrahedron Lett. 41: 703–706. doi:.
- K, Eisenreich W, Bacher A, Zenk MH (1999). "Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol". Proc. Natl. Acad. Sci. U. S. A. 96: 11758–63. doi:. PMID 10518523.
External links
Gene Ontology (GO) codes
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- This page was last modified on 21 June 2008, at 15:36.
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