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25I-NBOMe
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| Systematic (IUPAC) name | |
| 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C18H22INO3 |
| Mol. mass | 427.277 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
25I-NBOMe (NBOMe-2C-I or N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane) is a derivative of the phenethylamine hallucinogen 2C-I, discovered in 2006 by a team at Purdue University. It acts as a potent agonist for the 5HT2A receptor with a Ki of 0.087nM at the human 5HT2A receptor, making it some seven times the potency of 2C-I itself. In vitro tests showed this compound acted as an agonist but animal studies have not been reported. Interestingly while the N-benzyl derivatives of 2C-I were significantly increased in potency compared to 2C-I, the N-benzyl derivatives of DOI were inactive.1 Anecdotal reports from human users suggest 25I-NBOMe to be an active hallucinogen at a dose of as little as 500mcg, making it a similar potency to other phenethylamine derived hallucinogens such as bromo-dragonfly.2
References
- ^ Braden MR, Parrish JC, Naylor JC, Nichols DE. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Molecular Pharmacology. 2006 Dec;70(6):1956-64. PMID 17000863
- ^ "25B-NB (n-Benzyl-2C-B) - Bluelight".
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Wikipedia content modification information:
- This page was last modified on 19 November 2008, at 00:24.
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