4-dimethylaminophenol

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Not to be confused with 4-Dimethylaminopyridine.
4-Dimethylaminophenol
Identifiers
CAS number 619-60-3
PubChem 164849
SMILES
 
Properties
Molecular formula C8H11NO
Molar mass 137.179 g/mol
Boiling point

165 °C (0.040 bar)
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox references

4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.

Uses

4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.1

It works by generating methemoglobin. 2

This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.

In an animal model, it has shown effectiveness when given intramuscularly.3

See also

References

  1. ^ Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000). "Survival from a lethal blood concentration of cyanide with associated alcohol intoxication". Anaesthesia 55 (12): 1189–91. PMID 11121929. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0003-2409&date=2000&volume=55&issue=12&spage=1189. 
  2. ^ Vick JA, Von Bredow JD (1996). "Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival". J Appl Toxicol 16 (6): 509–16. doi:10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V. PMID 8956097. 
  3. ^ Vick JA, Froehlich H (July 1991). "Treatment of cyanide poisoning". Mil Med 156 (7): 330–9. PMID 1922842. 
v • d • e
Antidotes (V03AB)
Methanol / Ethylene glycol poisoning
Paracetamol toxicity (Acetaminophen)
Arsenic poisoning
Cyanide poisoning
Heparin
Nerve agent / Organophosphate poisoning
Opioid overdose
Barbiturate overdose
Benzodiazepine overdose
GHB overdose
Toxic metals (Cadmium, Mercury, Lead, Thallium)
Digoxin
Other
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Wikipedia content modification information:

  • This page was last modified on 1 January 2009, at 07:16.

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