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In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) is an enzyme that catalyzes the chemical reaction

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thus, the two substrates of this enzyme are ATP and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, whereas its two products are ADP and 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase. This enzyme is also called CDP-ME kinase. This enzyme participates in biosynthesis of steroids.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1OJ4, 1UEK, 2V2Q, 2V2V, 2V2Z, 2V34, and 2V8P.

References

• IUBMB entry for 2.7.1.148
• BRENDA references for 2.7.1.148 (Recommended.)
• PubMed references for 2.7.1.148
• PubMed Central references for 2.7.1.148
• Google Scholar references for 2.7.1.148
• Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W (2000). "Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol". Proc. Natl. Acad. Sci. U. S. A. 97: 1062–7. doi:10.1073/pnas.97.3.1062. PMID 10655484. 
• Seto H (2000). "Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase". Tetrahedron Lett. 41: 2925–2928. doi:10.1016/S0040-4039(00)00295-1. 

External links

• IUBMB entry for 2.7.1.148

• KEGG entry for 2.7.1.148

• BRENDA entry for 2.7.1.148

• NiceZyme view of 2.7.1.148

• EC2PDB: PDB structures for 2.7.1.148

• PRIAM entry for 2.7.1.148

• PUMA2 entry for 2.7.1.148

• IntEnz: Integrated Enzyme entry for 2.7.1.148

• MetaCyc entry for 2.7.1.148

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0050515: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

• AMIGO entry for GO code 0050515: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

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Wikipedia content modification information:

• This page was last modified on 21 June 2008, at 15:43.

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