This MedLibrary.org supplementary page on 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
In enzymology, a 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) is an enzyme that catalyzes the chemical reaction
- 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP
Hence, this enzyme has one substrate, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, and two products, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP.
This enzyme belongs to the family of lyases, specifically phosphorus-oxygen lyases. The systematic name of this enzyme class is 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming). Other names in common use include MECDP-synthase, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, and CMP-lyase (cyclizing). This enzyme participates in biosynthesis of steroids.
Contents |
Structural studies
As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes 1GX1, 1H47, 1H48, 1IV1, 1IV2, 1IV3, 1IV4, 1T0A, 1U3L, 1U3P, 1U40, 1U43, 1VH8, 1VHA, 1W55, 1W57, 1YQN, 2AMT, 2GZL, and 2PMP.
References
- IUBMB entry for 4.6.1.12
- BRENDA references for 4.6.1.12 (Recommended.)
- PubMed references for 4.6.1.12
- PubMed Central references for 4.6.1.12
- Google Scholar references for 4.6.1.12
- Fellermeier M, Eisenreich W, Zenk MH, Bacher A, Rohdich F (2000). "Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate". Proc. Natl. Acad. Sci. U. S. A. 97: 2486–90. doi:. PMID 10694574.
- Seto H (2000). "Studies on the nonmevalonate pathway: Formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol". Tetrahedron Lett. 41: 3395–3398. doi:.
External links
Gene Ontology (GO) codes
 |
This lyase article is a stub. You can help Wikipedia by expanding it. |
|
|||||
Wikipedia content modification information:
- This page was last modified on 21 June 2008, at 15:36.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.