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In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.4.3) is an enzyme that catalyzes the chemical reaction
- (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide
2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol
The 3 substrates of this enzyme are (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate, H2O, and protein disulfide, whereas its two products are 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and protein dithiol.
This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with a disulfide as acceptor. The systematic name of this enzyme class is (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating). This enzyme participates in biosynthesis of steroids.
References
- IUBMB entry for 1.17.4.3
- BRENDA references for 1.17.4.3 (Recommended.)
- PubMed references for 1.17.4.3
- PubMed Central references for 1.17.4.3
- Google Scholar references for 1.17.4.3
- D, Rohdich F (2001). "Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein". Proc. Natl. Acad. Sci. U. S. A. 98: 14837–42. doi:. PMID 11752431.
External links
Gene Ontology (GO) codes
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Wikipedia content modification information:
- This page was last modified on 28 September 2008, at 04:52.
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