4-hydroxyphenylpyruvate dioxygenase

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4-hydroxyphenylpyruvate dioxygenase
Identifiers
Symbol HPD
Alt. Symbols PPD;
Entrez 3242
HUGO 5147
OMIM 609695
RefSeq NM_002150
UniProt P32754
Other data
EC number 1.13.11.27
Locus Chr. 12 q24-qter

4-Hydroxyphenylpyruvate dioxygenase HPD is a Cu-containing enzyme, that catalyzes the third reaction in the catabolism of phenylalanine and tyrosine - the conversion of 4-hydroxyphenylpyruvate to homogentisate.

Function

The HPD reaction occurs through a NIH shift and involves the oxidative decarboxylation of an α-oxo acid as well as aromatic ring hydroxylation. The NIH-shift, which has been demonstrated through isotope-labeling studies, involves migration of an alkyl group to form a more stable carbocation. The shift, accounts for the observation that C3 is bonded to C4 in 4-hydroxyphenylpyruvate but to C5 in homogentisate.

The reaction mechanism of HPD.


See also

v • d • e
Oxidoreductases: monooxygenases (EC 1.13)
1.13.11 - two atoms of oxygen
1.13.12 - one atom of oxygen
1.13.99 - other
v • d • e
Metabolism: amino acid metabolism - synthesis and catabolism enzymes (essential in CAPS)
K→acetyl-CoA
(see below)
G→pyruvate
G→glutamate
G→propionyl-CoA
→succinyl-CoA→TCA
G→fumarate
G→oxaloacetate
Other
 This EC 1.13 enzyme-related article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 4 October 2008, at 02:28.

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