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5-Carboxamidotryptamine
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| Systematic (IUPAC) name | |
| 3-(2-aminoethyl)-1H-indole-5-carboxamide | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C11H13N3O |
| Mol. mass | 203.240 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
5-Carboxamidotryptamine (5-CT) is a drug which acts as a non-selective agonist at several different serotonin receptors. It was initially thought to be selective for 5HT11, but subsequent research showed that it also acts at 5HT2, 5HT3,2 5HT5 and 5HT7,3 although its strongest effect is at the 5HT1A subtype.4 However despite its lack of selectivity, 5-CT is still a useful compound and is widely used in scientific research.
References
- ^ Saxena PR, Lawang A. A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors. Archives Internationales de Pharmacodynamie et de Therapie. 1985 Oct;277(2):235-52. PMID 2933009
- ^ Wright CE, Angus JA. 5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets. Journal of Cardiovascular Pharmacology. 1989 Apr;13(4):557-64. PMID 2470992
- ^ Yamada J, Sugimoto Y, Noma T, Yoshikawa T. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. European Journal of Pharmacology. 1998 Oct 16;359(1):81-6. PMID 9831297
- ^ Thomas DR, Middlemiss DN, Taylor SG, Nelson P, Brown AM. 5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors. British Journal of Pharmacology. 1999 Sep;128(1):158-64. PMID 10498847
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Wikipedia content modification information:
- This page was last modified on 23 July 2008, at 02:42.
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