8a-Phenyldecahydroquinoline

This MedLibrary.org supplementary page on 8a-Phenyldecahydroquinoline is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

8a-Phenyldecahydroquinoline
Systematic (IUPAC) name
8a-phenyl-2,3,4,4a,5,6,7,8-octahydro-1H-quinoline
Identifiers
CAS number 131556-11-1
ATC code  ?
PubChem 131397
Chemical data
Formula C15H21N 
Mol. mass 215.3339 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

8a-Phenyldecahydroquinoline is a high affinity NMDA antagonist. It is a structural analog of Phencyclidine with slightly lower binding affinity than the parent compound. (-)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801.12

References

  1. ^ Chen C, Kozikowski AP, Wood PL, Reynolds IJ, Ball RG, Pang YP (1992). "Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency". J Med Chem 35 (9): 1634–8. doi:10.1021/jm00087a020. 
  2. ^ Elhallaoui M, Laguerre M, Carpy A, Ouazzani FC (2002). "Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode". J Mol Model 8 (2): 65–72. doi:10.1007/s00894-001-0067-4. 


Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Dissociative hallucinogens
Kappa agonists
NMDA receptor antagonists
Others
v • d • e
Glutamate receptor ligands
Ionotropic
Agonists; NMDA • Tetrazolylglycine
Antagonists; Competitive antagonists; AP7 • AP5 • CGP-37849 • Midafotel (CPPene) • PEAQX • Perzinfotel • PPDA • Sdz 220-581 • Selfotel; Noncompetitive antagonists; Aptiganel • Dizocilpine • FPL-12495 • FR-115,427 • Gacyclidine • Hodgkinsine • HU-211 • Indantadol • Psychotridine • Remacemide; Uncompetitive channel blockers; 2-MDP • 8a-Phenyldecahydroquinoline • Amantadine • Budipine • Delucemine • Dexoxadrol • Dextromethorphan • Dextrorphan • Endopsychosin • Etoxadrol • Eticyclidine • Ibogaine • Ketamine • Memantine • NEFA • Neramexane • Nitrous oxide • Phencyclidine • Rhynchophylline • Riluzole • Rolicyclidine • Tenocyclidine • Tiletamine • Xenon; Glycine site antagonists; 1-Aminocyclopropanecarboxylic acid • ACEA-1021 • 7-Chlorokynurenate • CGP-39653 • DCKA • Gavestinel • GV-150,526 • Kynurenic acid • L-689,560 • Lacosamide • ZD-9379; Polyamine site antagonists; Besonprodil • CP-101,606 • Eliprodil • Ifenprodil • Ro25-6981 • Traxoprodil; Indirect antagonists; Lubeluzole
Agonists; AMPA • Domoic acid • 5-Fluorowillardiine; Positive allosteric modulators; Aniracetam • Cyclothiazide • CX-516 • CX-546 • CX-614 • CX-691 • CX-717 • IDRA-21 • LY-392,098 • LY-404,187 • LY-451,395 • LY-451,646 • LY-503,430 • Oxiracetam • PEPA • Piracetam • Pramiracetam
Antagonists; ATPO • CNQX • DNQX • NBQX • Tezampanel (LY-293,558); Negative allosteric modulators; GYKI-53,655
Agonists; 5-Iodowillardiine • ATPA • Domoic acid • Kainic acid • LY-339,434 • SYM-2081
Antagonists; CNQX • DNQX • LY-382,884 • NBQX • NS102 • UBP-302; Negative allosteric modulators; NS-3763
Metabotropic
Agonists; Unselective; ACPD • Dihydroxyphenylglycine; mGlu1 selective; Ro01-6128; mGlu5 selective; CHPG • DFB
Antagonists; Unselective; MCPG; mGlu1 selective; BAY 36-7620 • CPCCOEt • LY-367,385; mGlu5 selective; LY-344,545 • MPEP • MTEP
Agonists; Unselective; Eglumegad (LY-354,740) • LY-404,039; mGlu2 selective; BINA • LY-487,379
Antagonists; EGLU • LY-341,495
Agonists; Unselective; AP4; mGlu4 selective; PHCCC; mGlu8 selective; DCPG
Antagonists; CPPG • UBP-1112

Wikipedia content modification information:

  • This page was last modified on 2 October 2008, at 15:19.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "8a-Phenyldecahydroquinoline".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.