ABCC10

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ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Identifiers
Symbols ABCC10; MRP7; EST182763; SIMRP7
External IDs MGI: 2386976 HomoloGene: 58616
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 89845 224814
Ensembl ENSG00000124574 ENSMUSG00000032842
Uniprot Q5T3U5 Q8R4P9
Refseq NM_033450 (mRNA)
NP_258261 (protein)		 NM_145140 (mRNA)
NP_660122 (protein)
Location Chr 6: 43.5 - 43.53 Mb Chr 17: 45.77 - 45.79 Mb
Pubmed search [1] [2]

ATP-binding cassette, sub-family C (CFTR/MRP), member 10, also known as ABCC10, is a human gene.[1]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[1]

Contents

See also

References

  1. ^ a b "Entrez Gene: ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10".

Further reading

  • Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum. Mol. Genet. 5 (10): 1649–55. PMID 8894702. 
  • Hopper E, Belinsky MG, Zeng H, et al. (2001). "Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily.". Cancer Lett. 162 (2): 181–91. PMID 11146224. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chen ZS, Hopper-Borge E, Belinsky MG, et al. (2003). "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).". Mol. Pharmacol. 63 (2): 351–8. PMID 12527806. 
  • Kao HH, Chang MS, Cheng JF, Huang JD (2003). "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7.". J. Biomed. Sci. 10 (1): 98–110. doi:10.1159/000068078. PMID 12566991. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Hopper-Borge E, Chen ZS, Shchaveleva I, et al. (2004). "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel.". Cancer Res. 64 (14): 4927–30. doi:10.1158/0008-5472.CAN-03-3111. PMID 15256465. 
  • Wooden SL, Kalb SR, Cotter RJ, Soloski MJ (2005). "Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis.". J. Immunol. 175 (3): 1383–7. PMID 16034073. 
  • Naramoto H, Uematsu T, Uchihashi T, et al. (2007). "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines.". Int. J. Oncol. 30 (2): 393–401. PMID 17203221. 

External links

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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12

B1, B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1-10
11-20
21-30
31-40
41-45
O
Other

Wikipedia content modification information:

  • This page was last modified on 9 July 2008, at 04:22.

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