ABCC13

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ATP-binding cassette, sub-family C (CFTR/MRP), member 13
Identifiers
Symbols ABCC13; C21orf73; PRED6
External IDs OMIM: 608835
Orthologs
Human Mouse
Entrez 150000 n/a



Pubmed search [1] n/a

ATP-binding cassette, sub-family C (CFTR/MRP), member 13, also known as ABCC13, is a human gene.[1]

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.[1]

See also

References

  1. ^ a b "Entrez Gene: ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13".

Further reading

  • Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates.". Annual review of genomics and human genetics 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856. 
  • Annilo T, Dean M (2005). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages.". Genomics 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202. 
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258. 
  • Brun ME, Ruault M, Ventura M, et al. (2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms.". Gene 312: 41–50. PMID 12909339. 
  • Yabuuchi H, Takayanagi S, Yoshinaga K, et al. (2003). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver.". Biochem. Biophys. Res. Commun. 299 (3): 410–7. PMID 12445816. 
  • Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.". Genomics 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
  • Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum. Mol. Genet. 5 (10): 1649–55. PMID 8894702. 
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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12

B1, B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1-10
11-20
21-30
31-40
41-45
O
Other

Wikipedia content modification information:

  • This page was last modified on 8 July 2008, at 17:34.

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