ABCG4

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ATP-binding cassette, sub-family G (WHITE), member 4
Identifiers
Symbols ABCG4; WHITE2
External IDs OMIM: 607784 MGI: 1890594 HomoloGene: 75179
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 64137 192663
Ensembl ENSG00000172350 n/a
Uniprot Q9H172 n/a
Refseq NM_022169 (mRNA)
NP_071452 (protein)		 XM_989152 (mRNA)
XP_994246 (protein)
Location Chr 11: 118.52 - 118.54 Mb n/a
Pubmed search [1] [2]

ATP-binding cassette, sub-family G (WHITE), member 4, also known as ABCG4, is a human gene.[1]

The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.[1]

Contents

See also

References

  1. ^ a b "Entrez Gene: ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4".

Further reading

  • Dean M, Rzhetsky A, Allikmets R (2001). "The human ATP-binding cassette (ABC) transporter superfamily.". Genome Res. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397. 
  • Engel T, Lorkowski S, Lueken A, et al. (2001). "The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages.". Biochem. Biophys. Res. Commun. 288 (2): 483–8. doi:10.1006/bbrc.2001.5756. PMID 11606068. 
  • Annilo T, Tammur J, Hutchinson A, et al. (2002). "Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4.". Cytogenet. Cell Genet. 94 (3-4): 196–201. PMID 11856881. 
  • Yoshikawa M, Yabuuchi H, Kuroiwa A, et al. (2002). "Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4.". Gene 293 (1-2): 67–75. PMID 12137944. 
  • Oldfield S, Lowry C, Ruddick J, Lightman S (2002). "ABCG4: a novel human white family ABC-transporter expressed in the brain and eye.". Biochim. Biophys. Acta 1591 (1-3): 175–9. PMID 12183068. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cserepes J, Szentpétery Z, Seres L, et al. (2004). "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.". Biochem. Biophys. Res. Commun. 320 (3): 860–7. doi:10.1016/j.bbrc.2004.06.037. PMID 15240127. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Engel T, Bode G, Lueken A, et al. (2006). "Expression and functional characterization of ABCG1 splice variant ABCG1(666).". FEBS Lett. 580 (18): 4551–9. doi:10.1016/j.febslet.2006.07.006. PMID 16870176. 
  • Vaughan AM, Oram JF (2007). "ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.". J. Lipid Res. 47 (11): 2433–43. doi:10.1194/jlr.M600218-JLR200. PMID 16902247. 

External links

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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12

B1, B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1-10
11-20
21-30
31-40
41-45
O
Other

[[Category:Solute carrier family]


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  • This page was last modified on 8 July 2008, at 14:39.

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