ADAM2

This MedLibrary.org supplementary page on ADAM2 is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

ADAM metallopeptidase domain 2 (fertilin beta)
Identifiers
Symbols ADAM2; CRYN1; CRYN2; FTNB; PH-30b; PH30
External IDs OMIM: 601533 MGI: 1340894 HomoloGene: 1127
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2515 11495
Ensembl ENSG00000104755 ENSMUSG00000022039
Uniprot Q99965 Q3TTP6
Refseq NM_001464 (mRNA)
NP_001455 (protein)		 NM_009618 (mRNA)
NP_033748 (protein)
Location Chr 8: 39.72 - 39.81 Mb Chr 14: 64.98 - 65.03 Mb
Pubmed search [1] [2]

ADAM metallopeptidase domain 2 (fertilin beta), also known as ADAM2, is a human gene.1

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.1

References

  1. ^ a b "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Eto K, Huet C, Tarui T, et al. (2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.". J. Biol. Chem. 277 (20): 17804–10. doi:10.1074/jbc.M200086200. PMID 11882657. 
  • Ikawa M, Nakanishi T, Yamada S, et al. (2002). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility.". Dev. Biol. 240 (1): 254–61. doi:10.1006/dbio.2001.0462. PMID 11784061. 
  • Cho C, Ge H, Branciforte D, et al. (2000). "Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion.". Dev. Biol. 222 (2): 289–95. doi:10.1006/dbio.2000.9703. PMID 10837118. 
  • Chen MS, Tung KS, Coonrod SA, et al. (1999). "Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11830–5. PMID 10518536. 
  • Chen H, Sampson NS (1999). "Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta.". Chem. Biol. 6 (1): 1–10. doi:10.1016/S1074-5521(99)80015-5. PMID 9889149. 
  • Burkin HR, Burkin DJ, Davey PM, et al. (1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB).". Genomics 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941. 
  • Vidaeus CM, von Kapp-Herr C, Golden WL, et al. (1997). "Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member.". Mol. Reprod. Dev. 46 (3): 363–9. doi:10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-#. PMID 9041139. 
  • Gupta SK, Alves K, Palladino LO, et al. (1996). "Molecular cloning of the human fertilin beta subunit.". Biochem. Biophys. Res. Commun. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389. 
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151. 
 This article on a gene on chromosome 8 is a stub. You can help Wikipedia by expanding it.
v • d • e
Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins
Alpha secretases (ADAM9 · ADAM10 · ADAM17 · ADAM19) · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13
Matrix metalloproteinase
Other


Wikipedia content modification information:

  • This page was last modified on 10 July 2008, at 08:31.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "ADAM2".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.