ADAM8

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ADAM metallopeptidase domain 8
Identifiers
Symbols ADAM8; CD156; MGC134985; MS2
External IDs OMIM: 602267 MGI: 107825 HomoloGene: 74384
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 101 11501
Ensembl ENSG00000151651 ENSMUSG00000025473
Uniprot P78325 Q3TVN5
Refseq NM_001109 (mRNA)
NP_001100 (protein)		 NM_007403 (mRNA)
NP_031429 (protein)
Location Chr 10: 134.93 - 134.94 Mb Chr 7: 139.83 - 139.84 Mb
Pubmed search [1] [2]

ADAM metallopeptidase domain 8, also known as ADAM8, is a human gene.1

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.1

See also

References

  1. ^ a b "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

Further reading

  • Yamamoto S, Higuchi Y, Yoshiyama K, et al. (1999). "ADAM family proteins in the immune system.". Immunol. Today 20 (6): 278–84. PMID 10354553. 
  • Yoshiyama K, Higuchi Y, Kataoka M, et al. (1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location.". Genomics 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482. 
  • Schlomann U, Rathke-Hartlieb S, Yamamoto S, et al. (2001). "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration.". J. Neurosci. 20 (21): 7964–71. PMID 11050116. 
  • Amour A, Knight CG, English WR, et al. (2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.". FEBS Lett. 524 (1-3): 154–8. PMID 12135759. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ishikawa N, Daigo Y, Yasui W, et al. (2005). "ADAM8 as a novel serological and histochemical marker for lung cancer.". Clin. Cancer Res. 10 (24): 8363–70. doi:10.1158/1078-0432.CCR-04-1436. PMID 15623614. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Foley SC, Mogas AK, Olivenstein R, et al. (2007). "Increased expression of ADAM33 and ADAM8 with disease progression in asthma.". J. Allergy Clin. Immunol. 119 (4): 863–71. doi:10.1016/j.jaci.2006.12.665. PMID 17339047. 
  • Gómez-Gaviro M, Domínguez-Luis M, Canchado J, et al. (2007). "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding.". J. Immunol. 178 (12): 8053–63. PMID 17548643. 
  • Valkovskaya N, Kayed H, Felix K, et al. (2008). "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer.". J. Cell. Mol. Med. 11 (5): 1162–74. doi:10.1111/j.1582-4934.2007.00082.x. PMID 17979891. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD78 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
v • d • e
Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins
Alpha secretases (ADAM9 · ADAM10 · ADAM17 · ADAM19) · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13
Matrix metalloproteinase
Other


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  • This page was last modified on 9 July 2008, at 04:42.

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