AMY2A

This MedLibrary.org supplementary page on AMY2A is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Amylase, alpha 2A; pancreatic
PDB rendering based on 1b2y.
Available structures: 1b2y, 1bsi, 1c8q, 1cpu, 1hny, 1jxj, 1jxk, 1kb3, 1kbb, 1kbk, 1kgu, 1kgw, 1kgx, 1mfu, 1mfv, 1nm9, 1q4n, 1smd, 1u2y, 1u30, 1u33, 1xcw, 1xcx, 1xd0, 1xd1, 1xgz, 1xh0, 1xh1, 1xh2, 1xv8, 1z32, 2cpu, 3cpu
Identifiers
Symbols AMY2A; AMY2; AMY2B; PA
External IDs OMIM: 104650 MGI: 88019 HomoloGene: 20179
Orthologs
Human Mouse
Entrez 279 11722
Ensembl n/a ENSMUSG00000074264
Uniprot n/a Q921Y7
Refseq NM_000699 (mRNA)
NP_000690 (protein)		 NM_007446 (mRNA)
NP_031472 (protein)
Location n/a Chr 3: 113.55 - 113.57 Mb
Pubmed search [1] [2]

Amylase, alpha 2A; pancreatic, also known as AMY2A, is a human gene.1

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.1

References

  1. ^ a b "Entrez Gene: AMY2A amylase, alpha 2A; pancreatic".

Further reading

  • Kaczmarek MJ, Rosenmund H (1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen.". Clin. Chim. Acta 79 (1): 69–73. PMID 890964. 
  • Jacob M, Lainé J, LeBel D (1993). "Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase.". Biochem. Cell Biol. 70 (10-11): 1105–14. PMID 1284286. 
  • Groot PC, Mager WH, Henriquez NV, et al. (1991). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers.". Genomics 8 (1): 97–105. PMID 2081604. 
  • Nishide T, Nakamura Y, Emi M, et al. (1986). "Primary structure of human salivary alpha-amylase gene.". Gene 41 (2-3): 299–304. PMID 2423416. 
  • Horii A, Emi M, Tomita N, et al. (1988). "Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene.". Gene 60 (1): 57–64. PMID 2450054. 
  • Gumucio DL, Wiebauer K, Caldwell RM, et al. (1988). "Concerted evolution of human amylase genes.". Mol. Cell. Biol. 8 (3): 1197–205. PMID 2452973. 
  • Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene.". Nucleic Acids Res. 16 (17): 8261–76. PMID 2458567. 
  • Groot PC, Bleeker MJ, Pronk JC, et al. (1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes.". Genomics 5 (1): 29–42. PMID 2788608. 
  • Groot PC, Bleeker MJ, Pronk JC, et al. (1988). "Human pancreatic amylase is encoded by two different genes.". Nucleic Acids Res. 16 (10): 4724. PMID 3260028. 
  • Wise RJ, Karn RC, Larsen SH, et al. (1986). "A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A.". Mol. Biol. Med. 2 (5): 307–22. PMID 6336237. 
  • Tricoli JV, Shows TB (1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1.". Somat. Cell Mol. Genet. 10 (2): 205–10. PMID 6608795. 
  • Nishide T, Emi M, Nakamura Y, Matsubara K (1984). "Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]". Gene 28 (2): 263–70. PMID 6610603. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Qian M, Haser R, Buisson G, et al. (1994). "The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution.". Biochemistry 33 (20): 6284–94. PMID 8193143. 
  • Brayer GD, Luo Y, Withers SG (1996). "The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes.". Protein Sci. 4 (9): 1730–42. PMID 8528071. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Rydberg EH, Sidhu G, Vo HC, et al. (1999). "Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris.". Protein Sci. 8 (3): 635–43. PMID 10091666. 
  • Brayer GD, Sidhu G, Maurus R, et al. (2000). "Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.". Biochemistry 39 (16): 4778–91. PMID 10769135. 
  • Aughsteen AA (2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas.". Saudi medical journal 22 (5): 410–5. PMID 11376382. 
  • Numao S, Maurus R, Sidhu G, et al. (2002). "Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.". Biochemistry 41 (1): 215–25. PMID 11772019. 
 This protein-related article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 9 July 2008, at 11:03.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "AMY2A".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.