ATP1A4

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ATPase, Na+/K+ transporting, alpha 4 polypeptide
Identifiers
Symbols ATP1A4; ATP1A1; ATP1AL2; MGC25056
External IDs OMIM: 607321 HomoloGene: 56958
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 480 n/a
Ensembl ENSG00000132681 n/a
Uniprot Q13733 n/a
Refseq NM_001001734 (mRNA)
NP_001001734 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 1: 158.39 - 158.42 Mb n/a
Pubmed search [1] n/a

ATPase, Na+/K+ transporting, alpha 4 polypeptide, also known as ATP1A4, is a human gene.[1]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

References

  1. ^ a b "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide".

Further reading

  • Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na, K-ATPase.". Prog. Nucleic Acid Res. Mol. Biol. 38: 37–89. PMID 2158121. 
  • Buetow KH, Nishimura D, Nakamura Y, et al. (1991). "A detailed multipoint gene map of chromosome 1q.". Genomics 8 (1): 13–21. PMID 1981991. 
  • Sverdlov ED, Broude NE, Sverdlov VE, et al. (1987). "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.". FEBS Lett. 221 (1): 129–33. PMID 2887455. 
  • Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit.". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039–43. PMID 3035563. 
  • Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.". FEBS Lett. 217 (2): 275–8. PMID 3036582. 
  • Shamraj OI, Lingrel JB (1995). "A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12952–6. PMID 7809153. 
  • Woo AL, James PF, Lingrel JB (1999). "Characterization of the fourth alpha isoform of the Na, K-ATPase.". J. Membr. Biol. 169 (1): 39–44. PMID 10227850. 
  • Woo AL, James PF, Lingrel JB (2000). "Sperm motility is dependent on a unique isoform of the Na, K-ATPase.". J. Biol. Chem. 275 (27): 20693–9. doi:10.1074/jbc. M002323200. PMID 10764792. 
  • Woo AL, James PF, Lingrel JB (2003). "Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility.". Mol. Reprod. Dev. 62 (3): 348–56. doi:10.1002/mrd.90002. PMID 12112599. 
  • Keryanov S, Gardner KL (2002). "Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4.". Gene 292 (1-2): 151–66. PMID 12119109. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lingrel J, Moseley A, Dostanic I, et al. (2003). "Functional roles of the alpha isoforms of the Na, K-ATPase.". Ann. N. Y. Acad. Sci. 986: 354–9. PMID 12763850. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Hlivko JT, Chakraborty S, Hlivko TJ, et al. (2006). "The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm.". Mol. Reprod. Dev. 73 (1): 101–15. doi:10.1002/mrd.20383. PMID 16175638. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Rodova M, Nguyen AN, Blanco G (2006). "The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform.". Mol. Reprod. Dev. 73 (11): 1435–47. doi:10.1002/mrd.20518. PMID 16894555. 
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Acid anhydride hydrolases: ATPases (EC 3.6.3-3.6.4)
3.6.3
3.6.4

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  • This page was last modified on 16 August 2008, at 03:53.

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