ATP1B1

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ATPase, Na+/K+ transporting, beta 1 polypeptide
Identifiers
Symbols ATP1B1; ATP1B; MGC1798
External IDs OMIM: 182330 MGI: 88108 HomoloGene: 37509
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 481 11931
Ensembl ENSG00000143153 ENSMUSG00000026576
Uniprot P05026 Q3TRA6
Refseq NM_001001787 (mRNA)
NP_001001787 (protein)		 NM_009721 (mRNA)
NP_033851 (protein)
Location Chr 1: 167.34 - 167.37 Mb Chr 1: 166.27 - 166.3 Mb
Pubmed search [1] [2]

ATPase, Na+/K+ transporting, beta 1 polypeptide, also known as ATP1B1, is a human gene.[1]

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

References

  1. ^ a b "Entrez Gene: ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide".

Further reading

  • Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase.". Prog. Nucleic Acid Res. Mol. Biol. 38: 37–89. PMID 2158121. 
  • Oakey RJ, Watson ML, Seldin MF (1993). "Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.". Hum. Mol. Genet. 1 (8): 613–20. PMID 1301170. 
  • Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R (1989). "Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression.". J. Biol. Chem. 264 (8): 4613–8. PMID 2538450. 
  • Ushkaryov YuA , Monastyrskaya GS, Broude NE, et al. (1990). "Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene.". FEBS Lett. 257 (2): 439–42. PMID 2555225. 
  • Lane LK, Shull MM, Whitmer KR, Lingrel JB (1990). "Characterization of two genes for the human Na,K-ATPase beta subunit.". Genomics 5 (3): 445–53. PMID 2559024. 
  • Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.". Genomics 2 (2): 128–38. PMID 2842249. 
  • Sverdlov ED, Broude NE, Sverdlov VE, et al. (1987). "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.". FEBS Lett. 221 (1): 129–33. PMID 2887455. 
  • Kawakami K, Nojima H, Ohta T, Nagano K (1986). "Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit.". Nucleic Acids Res. 14 (7): 2833–44. PMID 3008098. 
  • Coca-Prados M, Fernández-Cabezudo MJ, Sánchez-Torres J, et al. (1996). "Cell-specific expression of the human Na+,K(+)-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium.". Invest. Ophthalmol. Vis. Sci. 36 (13): 2717–28. PMID 7499094. 
  • Ruiz A, Bhat SP, Bok D (1995). "Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium.". Gene 155 (2): 179–84. PMID 7536695. 
  • Mobasheri A, Oukrif D, Dawodu SP, et al. (2001). "Isoforms of Na+, K+-ATPase in human prostate; specificity of expression and apical membrane polarization.". Histol. Histopathol. 16 (1): 141–54. PMID 11193188. 
  • Gamaleĭ IA, Polozov IuS, Aksenov ND, et al. (2001). "[Cell cycle and formation of active form of oxygen in rodent fibroblasts]". Tsitologiia 43 (6): 602–12. PMID 11534180. 
  • Béguin P, Crambert G, Monnet-Tschudi F, et al. (2002). "FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes.". EMBO J. 21 (13): 3264–73. doi:10.1093/emboj/cdf330. PMID 12093728. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. 
  • Fuller W, Eaton P, Bell JR, Shattock MJ (2004). "Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase.". FASEB J. 18 (1): 197–9. doi:10.1096/fj.03-0213fje. PMID 14597563. 
  • Li J, Codina J, Petroske E, et al. (2004). "The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function.". Kidney Int. 65 (4): 1301–10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wickham L, Benjannet S, Marcinkiewicz E, et al. (2005). "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.". J. Neurochem. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899. 
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