Acadesine

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Acadesine
Systematic (IUPAC) name
5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
Identifiers
CAS number 2627-69-2
ATC code  ?
PubChem 17513
Chemical data
Formula C9H14N4O5 
Mol. mass 258.231 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Acadesine (INN) (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) is an AMP-activated protein kinase activator1 which is used for the treatment of acute lymphoblastic leukemia2 and may have applications in treating other disorders such as diabetes.3

References

  1. ^ Favero CB, Mandell JW. A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain Research. 2007 Sep 7;1168:1-10. PMID 17706943
  2. ^ Cronstein BN, Kamen BA. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls? Journal of Pediatric Hematology and Oncology. 2007 Dec;29(12):805-7. PMID 18090925
  3. ^ Cuthbertson DJ, Babraj JA, Mustard KJ, Towler MC, Green KA, Wackerhage H, Leese GP, Baar K, Thomason-Hughes M, Sutherland C, Hardie DG, Rennie MJ. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men. Diabetes. 2007 Aug;56(8):2078-84. PMID 17513706
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