Acenocoumarol

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Acenocoumarol
Systematic (IUPAC) name
2-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-4H-
chromen-4-one
Identifiers
CAS number 152-72-7
ATC code B01AA07
PubChem 9052
Chemical data
Formula C19H15NO6 
Mol. mass 353.326 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 8 to 11 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

POM(UK)
Routes Oral

Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.

External links

  • DDB 29202
  • Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673–6. doi:10.1097/00001721-200412000-00007. PMID 15613922. 
  • Lengyel M (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619–21. PMID 15724697. 
  • Ufer M (2005). "Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227–46. doi:10.2165/00003088-200544120-00003. PMID 16372822. 
  • Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183–7. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310. 
v • d • e
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Vitamin K antagonists
Heparin group
Glycoprotein IIb/IIIa inhibitors
Other platelet
aggregation inhibitors
Enzymes
Direct thrombin inhibitors
Other antithrombotics
Non-medicinal
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Wikipedia content modification information:

  • This page was last modified on 1 June 2008, at 02:23.

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