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| Acquired pure red cell aplasia Classification and external resources |
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| ICD-10 | D60. |
|---|---|
| ICD-9 | 284.8 |
| DiseasesDB | 29063 |
| eMedicine | med/1967 |
| MeSH | D012010 |
Acquired pure red cell aplasia (or PRCA) refers to a type of anemia affecting the precursors to red blood cells but not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells.
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Causes
Pure red cell aplasia is regarded as an autoimmune disease. It may also be a manifestation of thymoma. It may also be as a result of viral infections such as HIV, herpes, parvovirus B19 (Fifth disease), or hepatitis. Association of pure red cell aplasia with T large granular lymphocyte leukemia is also well recognized, especially in China.[1] Many cases of PRCA are considered idiopathic in that there is no discernible cause detected.
It can be associated with the administration of erythropoietin.[2]
Treatment
PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as ciclosporin. It has also been shown to respond to treatments with Rituxan.
See also
- Diamond-Blackfan anemia (genetic red cell aplasia)
- aplastic anemia (aplasia affecting other bone marrow cells as well)
References
- ^ Kwong YL, Wong KF (1998). "Association of pure red cell aplasia with T large granular lymphocyte leukaemia". J. Clin. Pathol. 51 (9): 672–5. PMID 9930071. PMC:500904.
- ^ Bennett CL, Luminari S, Nissenson AR, et al (2004). "Pure red-cell aplasia and epoetin therapy". N. Engl. J. Med. 351 (14): 1403–8. doi:. PMID 15459301.
External links
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Wikipedia content modification information:
- This page was last modified on 29 July 2008, at 12:35.
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