Activin type 1 receptors

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The Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones include activin, Anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are three type I Activin receptors: ACVR1, ACVR1B, and ACVR1C. Each bind to a specific type II receptor-ligand complex.

Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a Type two receptor, which recruits and trans-phosphorylate a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The RSMAD then translocates to the nucleus where it functions as a transcription factor.

v • d • e
Cell signaling: TGF beta signaling pathway
TGF beta superfamily of ligands
TGF beta receptors
(Activin, BMP)
TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B)

TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2

TGFBR3: betaglycan
Transducers/SMAD
Ligand inhibitors
Coreceptors
Other
v • d • e
Receptors: growth factor receptors
Nerve growth factors
Somatomedin
CSF
TGF pathway
Other

Wikipedia content modification information:

  • This page was last modified on 9 December 2007, at 15:37.

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