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| Acute myeloblastic leukemia with maturation Classification and external resources |
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| Myeloblast | |
| ICD-O: | M9874/3 |
| MeSH | D015470 |
M2 is a subtype of AML (Acute Myeloid Leukemia).
It is also known as "Acute Myeloblastic Leukemia with Maturation".1
Cause
This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).2 On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes.
The two different proteins that are fused together are:
References
- ^ "Acute Myeloid Leukemia - Signs and Symptoms".
- ^ Taj AS, Ross FM, Vickers M, et al (1995). "t(8;21) myelodysplasia, an early presentation of M2 AML". Br. J. Haematol. 89 (4): 890-2. PMID 7772527.
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Wikipedia content modification information:
- This page was last modified on 14 September 2008, at 23:41.
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