Allobarbital

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Allobarbital
Systematic (IUPAC) name
5,5-diprop-2-enyl-1,3-diazinane-2,4,6-trione
Identifiers
CAS number 52-43-7
ATC code N05CA21
PubChem 5842
Chemical data
Formula C10H12N2O3 
Mol. mass 208.214 g/mol
SMILES eMolecules & PubChem
Synonyms 5,5-Diallylbarbituric acid, Allobarbital
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Allobarbital is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant [1] although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of analgesic drugs, and use in the treatment of insomnia and anxiety.

Allobarbital was never particularly widely used compared to better known barbiturates such as phenobarbital and secobarbital, although it saw more use in some European countries such as Bulgaria and Slovakia,[2] and is still used in some countries in Asia, Africa and the Middle East.


References

  1. ^ Chocholova L, Radil-Weiss T. Effect of allobarbital on focal epilepsy in rats. Physiologia Bohemoslovaca. 1971;20(4):325-34.
  2. ^ Getova D, Georgiev V. GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists. Acta Physiologica et Pharmacologica Bulgarica. 1987;13(3):43-50.
v • d • e
Barbiturates (N01AF, N03AA, N05CA)

Allobarbital • Alphenal • Amobarbital • Aprobarbital • Barbexaclone • Barbital • Brallobarbital • Brophebarbital • Bucolome • Butabarbital • Butalbital • Butobarbital • Butallylonal • Crotylbarbital • Cyclobarbital • Cyclopal • Enallylpropymal • Ethallobarbital • Febarbamate • Heptabarbital • Hexethal • Hexobarbital • Mephobarbital • Metharbital • Methohexital • Methylphenobarbital • Narcobarbital • Nealbarbital • Pentobarbital • Phenobarbital • Phetharbital • Prazitone • Probarbital • Propallylonal • Proxibarbal • Proxibarbital • Reposal • Secbutabarbital • Secobarbital • Sigmodal • Spirobarbital • Talbutal • Thialbarbital • Thiamylal • Thiobarbital • Thiobutabarbital • Thiopental • Valofane • Vinbarbital • Vinylbital
v • d • e
Psycholeptics: hypnotics and sedatives (N05C)
GABAA receptor
Alpha-2 adrenergic receptor
Melatonin receptor
Histamine receptor &
Acetylcholine receptor
GABAB receptor / GHB receptor
GHB Type
Other receptors/
ungrouped
Other

Wikipedia content modification information:

  • This page was last modified on 13 March 2008, at 18:51.

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