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Amnesic shellfish poisoning (ASP) is a human illness caused by consumption of the marine biotoxin called domoic acid.[1] This toxin is produced naturally by marine diatoms belonging to the genus Pseudo-nitzschia and, when accumulated in high concentrations by shellfish, can then be passed on to humans via consumption of contaminated shellfish. Although human illness due to domoic acid has only been associated with shellfish, the toxin can bioaccumulate in many marine organisms that consume phytoplankton, such as anchovies, and sardines. Intoxication by domoic acid in marine organisms is also referred to as "domoic acid poisoning". In mammals, including humans, domoic acid acts as a neurotoxin, causing permanent short-term memory loss, brain damage, and death in severe cases.
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Symptoms and treatment
In the brain, domoic acid especially damages the hippocampus and amygdaloid nucleus.[1] It damages the neurons by activating AMPA and kainate receptors, causing an influx of calcium. Although calcium flowing into cells is a normal event, the uncontrolled increase of calcium causes the cell to degenerate.
Gastrointestinal symptoms can appear 24 hours after ingestion of affected molluscs. They may include vomiting, nausea, diarrhea, abdominal cramps and haemorrhagic gastritis. In more severe cases there are neurological symptoms that can take several hours or up to three days to develop. These include headache, dizziness, disorientation, vision disturbances, loss of short-term memory, motor weakness, seizures, profuse respiratory secretions, hiccoughs, unstable blood pressure, cardiac arrhythmia, and coma.
People poisoned with very high doses of the toxin or displaying risk factors such as old age and renal failure can die. Death has occurred in 4 of 107 confirmed cases. In a few cases, permanent sequelae included short-term memory loss and peripheral polyneuropathy.
There is no known antidote available for domoic acid, so if symptoms fit the description, it is advised to quickly go to the hospital. Cooking or freezing affected fish or shellfish tissue does not lessen the toxicity.
Discovery
ASP was first discovered in humans late in 1987, when a serious outbreak of food poisoning occurred in eastern Canada.[1] Three elderly patients died and other victims suffered long-term neurological problems. Because the victims suffered from memory loss, the term "amnesic" shellfish poisoning is used.[2] The story made front-page newspaper headlines.
Epidemiologists from Health Canada quickly linked the illnesses to restaurant meals of cultured mussels harvested from one area in Prince Edward Island, a place never before affected by toxic algae. Mouse bioassays on aqueous extracts of the suspect mussels caused death with some unusual neurotoxic symptoms very different from those of paralytic shellfish poisoning toxins and other known toxins. On December 12, 1987, a team of scientists was assembled at the National Research Council of Canada laboratory in Halifax, Nova Scotia. Integrating bioassay-directed fractionation with chemical analysis, the team identified the toxin on the afternoon of December 16, just 4 days after the start of the concerted investigation.
Possible animal effects
On June 22, 2006, a California brown pelican, possibly under the influence of domoic acid, flew through the windshield of a car on the Pacific Coast Highway. The acid is found in the local seas.
Domoic acid poisoning may also have caused a 1961 invasion of thousands of frantic seabirds in Santa Cruz, California. Director Alfred Hitchcock heard about this invasion while working on his adaptation of Daphne du Maurier novella "The Birds" for his feature film The Birds (1963).
Since March 2007, marine mammal and seabird strandings and deaths off the Southern California coast have increased markedly. These incidents have been linked to the recent and dramatic increase of a naturally occurring toxin produced by algae. Most of the animals found dead tested positive for domoic acid.
References
- ^ a b c Clark RF, Williams SR, Nordt SP, Manoguerra AS (1999). "A review of selected seafood poisonings". Undersea Hyperb Med 26 (3): 175–84. PMID 10485519. Retrieved on 2008-08-12.
- ^ M. A. Quilliam, J. L. C. Wright, Anal. Chem., 61 (1989) 1053A
External links
- Amnesic Shellfish Poisoning at Woods Hole Oceanographic Institution
- Domoic acid at International Programme on Chemical Safety
- DOMOIC ACID - A MAJOR CONCERN TO WASHINGTON STATE’S SHELLFISH LOVERS at Washington Department of Fish and Wildlife
- Domoic acid and Pseudo-nitzschia references at Fisheries and Oceans Canada
- Crisis off our coast - International Bird Rescue Research Center
- http://www.healthebay.org/news/2007/04_30_domoicacid/default.asp
- CDC Disease Info marinetoxins_g
- http://www.whoi.edu/redtide/illness/asp.html
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- This page was last modified on 21 September 2008, at 18:11.
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