Amorolfine

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Amorolfine
Systematic (IUPAC) name
(2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4-
(2-methylbutan-2-yl)phenyl]propyl]morpholine
Identifiers
CAS number 78613-35-1
ATC code D01AE16
PubChem 54260
Chemical data
Formula C21H35N 
Mol. mass 317.509 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Amorolfine (or amorolfin), is an allylamine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.

Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.

v • d • e
Antifungals (D01 and J02)
Ergosterol inhibitors
Azoles
(CYP51A1 inhibitors)
topical: (Natamycin, Nystatin)
systemic: (Amphotericin B)
topical: (Amorolfine, Butenafine, Naftifine, Terbinafine)
systemic: (Terbinafine)
1,3-beta-glucan synthase
inhibitors
Intracellular
Others

Wikipedia content modification information:

  • This page was last modified on 23 May 2008, at 22:20.

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