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| Anacetrapib | |
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| IUPAC name | (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]- 3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4- (trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl}- 4-methyl-1,3-oxazolidin-2-one[1] |
| Identifiers | |
| CAS number | [875446-37-0] |
| PubChem | |
| Properties | |
| Molecular formula | C30H25F10NO3 |
| Molar mass | 637.51 g·mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Anacetrapib (USAN;[1] codenamed MK-0859, Merck) is a CETP inhibitor being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease. It is still in Phase I clinical trials; preliminary results appear encouraging,[2] although long-term safety data are lacking.
See also
- Torcetrapib, another CETP inhibitor unsuccessfully developed by Pfizer
References
- ^ a b "Statement on a nonproprietary name adopted by the USAN Council: Anacetrapib". American Medical Association (2007). Retrieved on 2008-01-19.
- ^ Krishna R, Anderson MS, Bergman AJ, et al (2007). "Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies". Lancet 370 (9603): 1907–14. doi:. PMID 18068514.
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