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| Anisomycin1 | |
|---|---|
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| IUPAC name | [(2S,3R,4R)-4-Hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate |
| Other names | Flagecidin |
| Identifiers | |
| CAS number | 22862-76-6 |
| PubChem | |
| SMILES |
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| Properties | |
| Molecular formula | C14H19NO4 |
| Molar mass | 265.31 g/mol |
| Melting point |
139-143 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Anisomycin, also known as flagecidin is an antibiotic produced by Streptomyces griseolus which inhibits protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis.2 Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
Anisomycin is inactive against bacteria.
Pharmacology
Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Anisomycin is also mentioned as a potential psychiatric drug, as it may inhibit the consolidation of new context-specific long-term memories.".3
Injection of anisomycin into the hippocampus has been proposed for selective removal of memories.4
See also
References
- ^ Anisomycin from Fermentek
- ^
Grollman AP (1967-07-10). "Inhibitors of protein biosynthesis. II. Mode of action of anisomycin". J. Biol. Chem. 242 (13): 3226–33. PMID 6027796. Free text (PDF - 990K) - ^ Barrientos RM, O'Reilly RC, Rudy JW (2002-08-21). "Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration". Behav. Brain Res. 134 (1-2): 299–306. doi:. PMID 12191817.
- ^ Wang SH, Ostlund SB, Nader K, Balleine BW (2005). "Consolidation and reconsolidation of incentive learning in the amygdala". J. Neurosci. 25 (4): 830–5. doi:. PMID 15673662. Free text
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- This page was last modified on 17 October 2008, at 07:11.
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