This MedLibrary.org supplementary page on Anti-tumor is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
Antineoplastics or "cytotoxics" (see also neoplastics) are drugs that inhibit and combat the development of tumors.
In the Anatomical Therapeutic Chemical Classification System, they are classified under L01D.
Contents |
Health effects/occupational exposure
The adverse health effects associated with antineoplastic agents (cancer chemotherapy drugs, cytotoxic drugs) in cancer patients and some non-cancer patients treated with these drugs are well-documented. The very nature of antineoplastic agents makes them harmful to healthy constantly dividing cells and tissues, as well as the cancerous cells. For cancer patients with a life-threatening disease, there is a great benefit to treatment with these agents. However, for the healthcare workers that are exposed to antineoplastic agents as part of their work practice, precautions should be taken to eliminate or reduce exposure as much as possible.There already is a limitation in cytotoxics dissolution in Australia and the United States to 20 dissolutions per pharmacist/nurse, since pharmacists that prepare these drugs or nurses that may prepare and/or administer them are the two occupational groups with the highest potential exposure to antineoplastic agents. In addition, physicians and operating room personnel may also be exposed through the treatment of patients. Hospital staff, such as shipping and receiving personnel, custodial workers, laundry workers, and waste handlers, all have potential exposure to these drugs during the course of their work. The increased use of antineoplastic agents in veterinary oncology also puts these workers at risk for exposure to these drugs.1
Modes of action
There are many classes of antineoplastics:
- Alkylating agents
- Antimetabolites
- Antimitotics: bind to tubulin and inhibit spindle dynamics and thus block cell division
- Inhibition of topoisomerase II, thereby stopping DNA from being unwound, which is required for both DNA replication and RNA/protein synthesis.
- Generating free radicals.
They are products of various strains of the soil bacteria Streptomyces.
Examples
- actinomycin (L01).
- The most important immunosuppressant from this group is dactinomycin, which is used to in kidney transplantations.
- anthracyclines
- doxorubicin (L01)
- daunorubicin (L01)
- Valrubicine
- Idarubicine
- epirubicin (L01), which also inhibit topoisomerase II)
- other cytotoxic antibiotics
- bleomycin (L01). Bleomycin acts in unique way through oxidation of a DNA-bleomycin-Fe(II) complex and forming free radicals, which induce damage and chromosomal aberrations.
- plicamycin (L01)
- mitomycin (L01)
References
- ^ "NIOSH Occupational Exposure to Antineoplastic Agents". United States National Institute for Occupational Safety and Health. Retrieved on 2007-10-10.
External links
- University of Nebraska
- Formulary by category
- MeSH Antineoplastics
- Antineoplastic at eMedicine Dictionary
- National Institute for Occupational Safety and Health - Occupational Exposure to Antineoplastic Agents
Wikipedia content modification information:
- This page was last modified on 18 November 2008, at 18:32.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Anti-tumor".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.