Antipyrine

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Phenazone
Systematic (IUPAC) name
1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
Identifiers
CAS number 60-80-0
ATC code N02BB01
PubChem 2206
DrugBank DB01435
ChemSpider 2121
Chemical data
Formula C11H12N2O 
Mol. mass 188.226
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Phenazone, or phenazon, is an analgesic. It was first synthesised by Ludwig Knorr in 1883. It is formed by reducing diortho-dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 C. It crystallizes in needles which melt at 156 C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid.

Contents

Synonyms

Analgesine, Antipyrine, Diméthyloxyquinazine, Oxydiméthylquinazine, Oxydiméthylquinizine, Pyrazoline

See also

Propyphenazone

Chimic Class

  • Pyrazole
  • Pyrazolinone

Pharmacology

Adverse effects

  • Allergy to pyrazolones
  • Nausea
  • Agranulocytosis
  • hepatotoxic
v • d • e
Anti-inflammatory and antirheumatic products (M01)
Anti-inflammatory and
antirheumatic products,
non-steroids
See also: NSAIDs
Acetic acid derivatives
and related substances
Propionic acid derivatives
Other
Specific antirheumatic
agents
Other
v • d • e
Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Sulphonanilides
Topically used products
COX-inhibiting nitric oxide donators
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.
v • d • e
Analgesic products (N02A, N02B)
Opioids
See also: Opioids template
Opium & alkaloids thereof
Semi-synthetic opium
derivatives
Synthetic opioids
Pyrazolones
Cannabinoids
Anilides
Non-steroidal
anti-inflammatories
See also: NSAIDs template
Propionic acid class
Oxicam class
Acetic acid class
Anthranilic acid
(fenamate) class
Atypical, adjunct
& miscellaneous

Wikipedia content modification information:

  • This page was last modified on 15 September 2008, at 03:31.

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