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| Apiol | |
|---|---|
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| IUPAC name | 1-allyl-2,5-dimethoxy- 3,4-methylenedioxybenzene |
| Identifiers | |
| CAS number | [523-80-8] |
| SMILES |
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| Properties | |
| Molecular formula | C12H14O4 |
| Molar mass | 222.23 g/mol |
| Melting point |
30 °C |
| Boiling point |
294 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Apiol is an organic chemical compound, also known as parsley apiol, apiole or parsley camphor. It is found in celery, parsley seeds, and the essential oil of parsley. Heinrich Christoph Link, an apothecary in Leipzig, discovered the substance in 1715 as greenish crystals reduced by steam from oil of parsley. In 1855 Joret and Homolle discovered that apiol was an effective treatment of amenorrea or lack of menstruation.
In medicine it has been used, as essential oil or in purified form, for the treatment of menstrual disorders. It is an irritant and in high doses it is toxic and can cause liver and kidney damage.
Hippocrates wrote about parsley as a herb to cause an abortion. This effect was caused by the apiol.
Apiol was used by women in the Middle Ages to terminate pregnancies.citation needed Its use was widespread in the USA, often as ergoapiol or apergol, until a highly toxic adulterated product containing apiol and tri-orthocresyl phosphate (also famous as the adulterant added to Jamaican ginger) was introduced on the American market.
The toxic effects of pure crystalline apiol are disputed. It causes a "relatively safe abortion" in pregnant women if taken in small quantities. It also restores the cycle of menstruation. A larger dose does not cause an abortion, it causes nausea and damages the liver and kidneys.citation needed
Now that other methods of abortion are available apiol is almost forgotten in the West, but it is still produced and is used in the Middle East.citation needed
The name apiol is also used for other closely related compounds, found in dill (dillapiole, 1-allyl-2,3-dimethoxy-4,5-methylenedioxybenzene) and in fennel roots.
External links
- The British Pharmaceutical Codex 1911: Apiol
- Apiol chemical information from chemindustry.com
- NIH ChemIDplus: Apiole)
- Essential oil from fennel plants--studies on the composition
References
 |
The references used in this article may be clearer with a different or consistent style of citation, footnoting, or external linking. (September 2007) |
- Edward Shorter: A history of women's bodies New York 1982 Bulletin géneral de thérapeutique médicale, No. 158, 1909 (A history of apiol and abortions)
Wikipedia content modification information:
- This page was last modified on 8 July 2008, at 23:17.
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