Arotinolol

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Arotinolol
Systematic (IUPAC) name
5-(2-{[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl}- 1,3-thiazol-4-yl)thiophene-2-carboxamide
Identifiers
CAS number 41287-43-8
ATC code  ?
PubChem 2239
Chemical data
Formula C15H21N3O2S3 
Mol. mass 371.54 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

℞ Prescription only
Routes Oral

Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. 1

Uses

It is used in the treatment of high blood pressure.2

It has been proposed for use in treatment of essential tremor.3

References

  1. ^ Zhao J, Golozoubova V, Cannon B, Nedergaard J (July 2001). "Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes". Can. J. Physiol. Pharmacol. 79 (7): 585–93. PMID 11478592, http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0008-4212&volume=79&issue=7&startPage=585. 
  2. ^ Wu H, Zhang Y, Huang J, et al (September 2001). "Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers". Hypertens. Res. 24 (5): 605–10. PMID 11675958, http://joi.jlc.jst.go.jp/JST.JSTAGE/hypres/24.605?from=PubMed. 
  3. ^ Lee KS, Kim JS, Kim JW, Lee WY, Jeon BS, Kim D (August 2003). "A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor". Parkinsonism Relat. Disord. 9 (6): 341–7. PMID 12853233, http://linkinghub.elsevier.com/retrieve/pii/S1353802003000294. 

External links

Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Adrenergic antagonists
α
Non-selective α
reversible (Phentolamine) · irreversible (Phenoxybenzamine)
Ungrouped
β
β1 selective
(cardioselective)
Mixed α1/β
Carvedilol · Labetalol · Arotinolol
Indirect
tyrosine hydroxylase inhibitor (Metirosine) · vesicle storage inhibitor (Reserpine) · neurotransmitter release blocker (Guanethidine, Bretylium)

Wikipedia content modification information:

  • This page was last modified on 15 August 2008, at 18:33.

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