Asmanex

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Mometasone furoate
Systematic (IUPAC) name
(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16

-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
Identifiers
CAS number 105102-22-5 83919-23-7 as Furoate
ATC code D07AC13 D07XC03, R01AD09, R03BA07
PubChem 123620
DrugBank APRD00289
Chemical data
Formula C22H28Cl2O4 for Mometasone
C27H30O6Cl2 as Furoate
Mol. mass 427.361 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability Nasal spray is virtually undetectable in plasma
Protein binding 98% to 99%
Metabolism hepatic
Half life 5.8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes topical, nasal

Mometasone furoate (also referred to as Mometasone) is a moderately potent glucocorticoid steroid used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), and asthma for patients unresponsive to less potent corticosteroids. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.

Generic Mometasone cream made by Glenmark (India)

Schering-Plough markets the medication under the following brand names; Elocon (Elocom) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflamation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. It is also available as a generic.

Nasonex is known in the U.S. for a series of television ads featuring an animated bee which is voiced by the Spanish actor Antonio Banderas.12



References

  1. ^ "Antonio Banderas - Other Works". Internet Movie Database.
  2. ^ ""Antonio Banderas Dons The Mask Once More"". Washington Post.

External links



Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
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v • d • e
Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)
Mineralocorticoids
Glucocorticoids
Other/ungrouped
corticosteroids
Aldosterone antagonists
Synthesis
v • d • e
Decongestants and other nasal preparations (R01)
Topical
Antiallergic agents,
excluding corticosteroids
Other nasal preparations
Systemic use:
Sympathomimetics

Wikipedia content modification information:

  • This page was last modified on 17 November 2008, at 08:34.

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