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| Autoimmune hemolytic anemia Classification and external resources |
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| ICD-10 | D59.0-D59.1 |
|---|---|
| ICD-9 | 283.0 |
| MeSH | D000744 |
Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction (hemolysis). Antibodies and associated complement system components become fixed onto the RBC surface. These antibodies can be detected with the direct antiglobulin test, also known as the direct Coombs test. AIHA can also be induced by several drugs including methyldopa and fludarabine.
Autoimmunity must not be confused with alloimmunity.
Contents |
Classification
Haemolysis can be intravascular or extravascular.
Intravascular haemolysis
Red blood cell lysis occurs in the circulation as a result of activation of the complement system cascade.
Extravascular haemolysis
Red Blood Cells that are coated with antibodies are specifically recognised in the reticuloendothelial system and destroyed by macrophages.
Subtypes
Warm antibody autoimmune hemolytic anemia
- Idiopathic
- Systemic lupus erythematosus
- Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
- Chronic lymphocytic leukemia
- Drugs (methyldopa)
Cold antibody autoimmune hemolytic anemia
- Idiopathic cold hemagglutinin syndrome
- Infectious mononucleosis
- Paroxysmal cold hemoglobinuria (rare)
- Lymphoma
Mixed-type autoimmune hemolytic anemia
Laboratory findings
- Positive direct Coombs test
- Anaemia
See also
References
External links
- Case report of Autoimmune Hemolytic Anemia with typical laboratory findings. Clinical Cases and Images.
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- This page was last modified on 25 August 2008, at 19:14.
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