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Breakpoint cluster region
PDB rendering based on 1k1f.
Available structures: 1k1f
Identifiers
Symbols	BCR; ALL; BCR/FGFR1; BCR1; CML; D22S11; D22S662; FGFR1/BCR; FLJ16453; PHL
External IDs	OMIM: 151410 MGI: 88141 HomoloGene: 3192
Gene ontology Molecular function: • molecular_function • protein serine/threonine kinase activity • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • GTPase activator activity • kinase activity • transferase activity Cellular component: • cellular_component • intracellular Biological process: • protein amino acid phosphorylation • signal transduction • intracellular signaling cascade • biological_process • regulation of Rho protein signal transduction
Orthologs
	Human	Mouse
Entrez	613	110279
Ensembl	n/a	ENSMUSG00000009681
Refseq	NM_004327 (mRNA) NP_004318 (protein)	XM_898043 (mRNA) XP_903136 (protein)
Location	n/a	Chr 10: 74.51 - 74.63 Mb
Pubmed search	[1]	[2]

The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.

Pathology

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.¹

See also

• Abl gene

External links

• MeSH BCR+protein,+human

References

Further reading

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Wikipedia content modification information:

• This page was last modified on 23 July 2008, at 07:38.

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