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BEACOPP is a chemotherapy regimen for treatment of Hodgkin's lymphoma in Stages > II. Patients typically receive treatment in cycles of 21 days with no drugs given on days 16-21. There also exists a more intensive regimen with cycles of 14 days. Usually a therapy consists of eight, sometimes six cycles. In some countries BEACOPP still is experimental, in others (e.g. Germany and Austria) it is a standard therapy. In the United States, ABVD (or Stanford V) is generally given instead, because BEACOPP is thought to induce more secondary neoplasias (such as leukemias)citation needed. This has not been proven after 10 years of experience in other countries. Some consider that the BEACOPP regimen is not generally given for cost reasonscitation needed; it is indeed more expensive as it requires G-CSF support. However, BEACOPP delivers approximately 10-15% more cures in advanced Hodgkin's disease (IIB+risk factors or stages III and IV)citation needed.
m² = body surface
i.v. = intravenous
BEACOPP basic:
| (C)yclophosphamide | 650 mg/m² | (i.v.) | day 1 |
| (A)driamycin | 25 mg/m² | i.v. | day 1 |
| (E)toposide | 100 mg/m² | i.v. | day 1-3 |
| Vincristin(=(O)ncovin) | 1,4 mg/m² (max 2 mg) | i.v. | day 8 |
| (B)leomycin | 10 mg/m² | i.v. | day 8 |
| (P)rocarbazine | 100 mg/m² | orally | day 1-7 |
| (P)rednisone | 40 mg/m² | orally | day 1-14 |
BEACOPP escalated:
| Cyclophosphamide | 1250 mg/m² KO/day | i.v. | day 1 |
| Adriamycin | 35 mg/m² | i.v. | day 1 |
| Etoposide | 200 mg/m² | i.v. | day 1-3 |
| Vincristine | 1,4 mg/m² (max 2 mg) | i.v. | day 8 |
| Bleomycin | 10 mg/m² | i.v. | day 8 |
| Procarbazine | 100 mg/m² | orally | day 1-7 |
| Prednisone | 40 mg/m² | orally | day 1-14 |
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- This page was last modified on 17 November 2008, at 17:24.
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