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| Bone morphogenetic protein receptor, type IB | |
|---|---|
| Other names: | CDw293 antigen |
| Genetic data | |
| Gene code: | HUGO code:BMPR1B |
| Protein Structure/Function | |
| Protein type: | Receptor serine/threonine kinase |
| Domains: | TM domain S/T domain, GS domain |
| Other | |
| Taxa expressing: | Homo sapiens: homologs: many metazoan phyla |
| Cell types: | many |
| Subcellular localization: | Plasma membrane |
| Enzymatic Data | |
| Catalytic activity: | ATP + (receptor-protein) = ADP + receptor-protein phosphate |
| Cofactor(s): | Magnesium or manganese |
| Medical/Biotechnological data | |
| Diseases: | Acromesomelic chondrodysplasia with genital anomalies Online 'Mendelian Inheritance in Man' (OMIM) 609441; Brachydactyly type A2 (BDA2) Online 'Mendelian Inheritance in Man' (OMIM) 112600 |
The BMPR1B receptor plays a role in the formation of middle and proximal phalanges.1 BMPR1B has also been designated as CDw293 (cluster of differentiation w293).
In the chick embryo, it has been shown that BMPR1B is found in precartilaginous condensations.2 BMPR1B is the major transducer of signals in these condensations as demonstrated in experiments using constitutively active BMPR1B receptors.2 BMPR1B is a more effective trasducer of GDF5 than BMPR1A.2 Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.2
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References
- ^ Mishina Y, Starbuck MW, Gentile MA, Fukuda T, Kasparcova V, Seedor JG, Hanks MC, Amling M, Pinero GJ, Harada S, Behringer RR (2004). "Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling". J. Biol. Chem. 279 (26): 27560–6. doi:. PMID 15090551.
- ^ a b c d Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM (2005). "Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo". Proc. Natl. Acad. Sci. U.S.A. 102 (14): 5062–7. doi:. PMID 15781876.
External links
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Wikipedia content modification information:
- This page was last modified on 6 March 2008, at 06:15.
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